HapMap tagSNP transferability in multiple populations: General guidelines
نویسندگان
چکیده
منابع مشابه
The Whole Genome TagSNP Selection and Transferability Among HapMap Populations
One of the crucial issues of association studies is the selection of markers. One possible approach would be to select tagging SNPs (tSNPs) according the HapMap information. In this study we present the number of tSNPs required for the association analysis of the entire human genome for all available HapMap population samples: CEPH, Nigerian, Chinese and Japanese. For future association studies...
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The rapidly growing amount of genomic sequence data being generated and made publicly available necessitate the development of new data storage and archiving methods. The vast amount of data being shared and manipulated also create new challenges for network resources. Thus, developing advanced data compression techniques is becoming an integral part of data production and analysis. The HapMap ...
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UNLABELLED Understanding of human variation relevant to association studies can benefit from population comparison, especially comparing populations in the same geographical region. Variations in linkage disequilibrium patterns, in tagSNP sets, and in SNP heterozygosities among populations can be used to infer the evolutionary pattern. We present here a win32 system based Perl/Tk application fo...
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The discovery of block-like structure of linkage disequilibrium (LD) in human populations holds the promise in delineating etiology of common diseases. However, understanding of the magnitude, mechanism, and utility of between-population LD sharing are critical for future genome-wide association studies. In this study, substantial LD sharing between six non-African populations was observed, tho...
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Correct annotation of the genetic relationships between samples is essential for population genomic studies, which could be biased by errors or omissions. To this end, we used identity-by-state (IBS) and identity-by-descent (IBD) methods to assess genetic relatedness of individuals within HapMap phase III data. We analyzed data from 1,397 individuals across 11 ethnic populations. Our results su...
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ژورنال
عنوان ژورنال: Genomics
سال: 2008
ISSN: 0888-7543
DOI: 10.1016/j.ygeno.2008.03.011